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Assessment Cytotoxic effects of sea cucumber Holothuria parva extracted fraction from the port of Dir (Persian Gulf) on the colon cancer cell line HT29
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Fatemeh Nabavi Moghadam   , Sohrab Boozarpour  , Amir Vazirizadeh , Sirous Naeimi , Mohammad Gholizadeh |
| Gonbad Kavous University , so.boozarpour@gmail.com |
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Abstract: (18 Views) |
Background and Objectives: Marine plants and animals are extremely diverse, with approximately 14,000 medicinal compounds isolated from them. However, the oceans are a largely untapped resource of anticancer agents. Sea cucumber is a marine invertebrate from the class Holothuroidea, which has a valuable and unique profile of nutrients and medicinal properties. The aim of the present study was to investigate the effect of sea cucumber extract on colon cancer cell death
.Methods: In the present study, the anticancer effects of Holothuria parva extracts were investigated using solvents with different polarities including normal hexane, ethanol and water on the HT29 colon cancer cell line using the MTT assay. The anticancer effects of the extracts were investigated at three times: 24, 48 and 72 hours.
Findings: The results showed that treatment of human colon cancer cell line HT29 with water-soluble sea cucumber extract had the highest lethal effect on cancer cells after 72 hours. Also, the lethality assay of sea cucumber extract on Artemia urmiana nauplii showed that these extracts had a mild lethal effect on Artemia.
Conclusion: Due to the high cytotoxicity of cucumber aqueous extract on the HT29 cell line, these compounds can be introduced as suitable candidates for the production of drugs with anti-colon cancer properties after purification. |
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| Keywords: Sea Cucumbers, Extract, Cytotoxicity Tests, Cell lineو, Colorectal Neoplasms |
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Type of Study: Research/ Original/ Regular Article |
Subject:
Marine Biology
Received: 2025/08/16 | Revised: 2026/05/3 | Accepted: 2026/03/6
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